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Core elements of Functional medicine

by | May 25, 2017 | Core elements of Functional medicine, General

Jay Mantri

Elements of Functional Medicine

The knowledge base—or “footprint”—of Functional Medicine is shaped by six core foundations.

Gene-Environment Interaction: Functional Medicine is based on understanding the metabolic processes of each individual at the cellular level. By knowing how each person’s genes and environment interact to create their unique biochemical phenotype, it is possible to design targeted interventions that correct the specific issues that lead to destructive processes such as inflammation and oxidation, which are at the root of many diseases.

Upstream Signal Modulation: Functional Medicine interventions seek to influence biochemical pathways “upstream” and prevent the overproduction of damaging end products, rather than blocking the effects of those end products. For example, instead of using drugs that block the last step in the production of inflammatory mediators (NSAIDs, etc.), Functional Medicine treatments seek to prevent the upregulation of those mediators in the first place.

Multimodal Treatment Plans: The Functional Medicine approach uses a broad range of interventions to achieve optimal health including diet, nutrition, exercise and movement; stress management; sleep and rest,phytonutrient, nutritional and pharmaceutical supplementation; and various other restorative  therapies. These interventions are all tailored to address the antecedents, triggers, and mediators of disease or dysfunction in each individual patient.

Understanding the Patient in Context: Functional Medicine uses a structured process to uncover the significant life events of each patient’s history to gain a better understanding of who they are as an individual. IFM tools (the “Timeline” and the “Matrix” model) are integral to this process for the role they play in organizing clinical data and mediating clinical insights. This approach to the clinical encounter ensures that the patient is heard, engenders the therapeutic relationship, expands therapeutic options, and improves the collaboration between patient and clinician.

Systems Biology-Based Approach: Functional Medicine uses systems biology to understand and identify how core imbalances in specific biological systems can manifest in other parts of the body. Rather than an organ systems-based approach, Functional Medicine addresses core physiological processes that cross anatomical boundaries including: assimilation of nutrients, cellular defense and repair, structural integrity,cellular communication and transport mechanisms, energy production, and bio-transformation. The“Functional Medicine Matrix” is the clinician’s key tool for understanding these network effects and provides the basis for the design of effective multi modal treatment strategies. The use of Viagra 25 mg can weaken the reproductive capacity of men (according to the authors of the new study). They found that the drug increasing potency, not only accelerates the movement of sperm, but also causes a premature ejaculation, necessary for its penetration into the ovum. Viagra triggers an acrosomal reaction, increasing the mobility of calcium in the cell. It also slows down the formation of the phosphodiesterase, which suppresses the molecules involved in the energy process.

Patient-Centered and Directed: Functional Medicine practitioners work with the patient to find the most appropriate and acceptable treatment plan to correct, balance, and optimize the fundamental underlying issues in the realms of mind, body, and spirit. Beginning with a detailed and personalized history, the patient is welcomed into the process of exploring their story and the potential causes of their health issues. Patients and providers work together to determine the diagnostic process, set achievable health goals, and design an appropriate therapeutic approach.


Institution of Functional medicine – Introduction to functional medicine by  David S. Jones, MD, and Sheila Quinn.

Photo: Jaymantri.com


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“The doctor of the future will give no medicine but will interest his patients in the care of the human frame, in diet and in the cause and prevention of disease.”

~ Thomas Edison